Therapeutic targeting of the mevalonate–geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer

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DOI:10.1038/s43018-022-00358-1
作者：Chenchen Guo, Ruijie Wan, Yayi He, Shu-Hai Lin, Jiayu Cao, Ying Qiu, Tengfei Zhang, Qiqi Zhao, Yujia Niu, Yujuan Jin, Hsin-Yi Huang, Xue Wang,&nb
文献类型：期刊论文
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Nature

Abstract：Small cell lung cancer (SCLC) lacks effective treatments to overcome chemoresistance. Here we established multiple human chemoresistant xenograft models through long-term intermittent chemot

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