In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor.

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DOI:10.1080/00498254.2024.2389407
作者：Rajaa Sukhun,?Peadar Cremin,?Donghong Xu,?Jeanelle Zamora,?Jennifer Cheung,?Luke Ashcraft,?Mark P Grillo,?Bradley P Morgan
文献类型：期刊论文
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Taylor & Francis

Abstract：Aficamten, a small molecule selective inhibitor of cardiac myosin, was characterised in preclinical in vitro and in vivo studies.Protein binding in human plasma was 10.4% unbound and ranged

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