Discovery of a Highly Potent and Selective Tyrosine Kinase 2 (TYK2) Degrader with In Vivo Therapeutic Efficacy in a Murine Psoriasis Model

已完结 10 由向阳的向日葵发布于 2025/3/31 14:33:44

DOI:10.1021/acs.jmedchem.5c00027
作者：Shuangshuang Xiong, Jiaqi Yang, Ming Yang, Maoxu Xiao, Si Ha, Wenxiang Tao, Luyu Ma, Chenxuan Ji, Hua Xiang, Guoshun Luo
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：Tyrosine kinase 2 (TYK2), a critical scaffolding kinase required for type I interferon, IL-12 and IL-23 cytokine signaling, represents a compelling therapeutic target for various autoimmune

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