Discovery and Optimization of a Series of Novel Morpholine-Containing USP1 Inhibitors

已完结 10 由小小发布于 2025/4/7 15:41:50

DOI:10.1021/acs.jmedchem.4c02792
作者：Junjie Zhang, Benjin Liu, Ruyue Ren, Shanshan Song, Xubin Bao, Xiajuan Huan, Hongrui Li, Jiahao Xu, Ting Yu, Ruifeng Wang, Ze-Hong Miao, Bing Xiong, Jinxue He, Tongchao Liu
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Ubiquitin-specific protease 1 (USP1), a well-known member of the deubiquitinating enzymes, serves as a key regulator in DNA damage repair (DDR) processes. Herein, we utilized ring-opening an

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