Structure–Activity Relationship Studies of 2,4,5-Trisubstituted Pyrimidine Derivatives Leading to the Identification of a Novel and Potent Sirtuin 5 Inhibitor against Sepsis-Associated Acute Kidney Injury

已完结 10 由络络发布于 2025/4/15 0:37:15

DOI:10.1021/acs.jmedchem.3c01031
作者：Luohe Mou, Lina Yang, Shuyan Hou, Bo Wang, Xinyue Wang, Lei Hu, Jianlin Deng, Jiayu Liu, Xi Chen, Yingying Jiang, Weifeng Zhang, Pengcheng Lei,&n
文献类型：期刊论文
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文献链接：https://doi.org/10.1021/acs.jmedchem.3c01031

American Chemical Society (ACS)

Abstract：Sepsis-associated acute kidney injury (AKI) is a serious clinical problem without effective drugs. Inhibition of sirtuin 5 (SIRT5) has been confirmed to protect against AKI, suggesting that

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