Enabling the First Scale-Up of the Selective HER2 Inhibitor BI-4142

已完结 10 由小姚发布于 2025/6/5 15:57:06

DOI:10.1021/acs.oprd.5c00127
作者：Eugene Chong, Ruoshi Li, Weitong Dong, Maxim Chevliakov, Thomas G. Tampone, Yongda Zhang, Bo Qu, Nizar Haddad, Jon C. Lorenz, Max Sarvestani, Thuraya Omar, Huayu Li, Joe J. Gao, Donghong A. Gao, Scott
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：The enabling synthesis of the first route to HER2 inhibitor BI-4142 (1) to deliver a drug substance in kilogram quantity is reported. The synthetic route involves (1) a fit-for-purpose synth

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