First-in-Human Study on Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Escalating Doses of HEC88473, a Novel Dual GLP-1 and FGF21 Receptor Agonist in Healthy and Obese Chinese Subjects.

已完结 10 由 xiaoshen 发布于 2025/6/9 16:46:12

DOI:10.1007/s40259-025-00715-3
作者：Hong Zhang,?Qianqian Li,?Hong Chen,?Lingfeng Guo,?Jing Li,?Can Xie,?Jiangyu Yan,?Yanhua Ding
文献类型：期刊论文
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Springer

Abstract：Background: HEC88473 is a novel long-acting dual agonist of glucagon-like peptide 1 (GLP-1) and fibroblast growth factor 21 (FGF21) receptors. It is a Fc fusion protein containing a fibrobla

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