Suppression of Simultaneous Fmoc-His(Trt)-OH Racemization and Nα-DIC-Endcapping in Solid-Phase Peptide Synthesis through Design of Experiments and Its Implication for an Amino Acid Activation Strategy in Peptide Synthesis

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DOI:10.1021/acs.oprd.2c00144
作者：Yi Yang*,?Lena Hansen and Alberto Baldi,?
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Coupling Fmoc-His(Trt)-OH in solid-phase peptide synthesis is frequently accompanied by significant racemization. Histidine is among the most susceptible amino acid residues inclined to race

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