Nanobody-Engineered Bispecific IL-18 Mimetics Drive Antitumor Immunity by Engaging CD8+ T Cells and Evading IL-18BP in Preclinical Models.

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DOI:10.1016/j.ymthe.2025.07.004
作者：Yanyang Nan,Min Zhu,Qian Wang,Xiaoxue Du,Caili Xu,Yuping Huang,Yujie Liu,Shaoyuan Zhou,Yuluoyan Qiu,Xiao Chu,Dianwen Ju,Yakun Wan,Xuyao Zhang
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1016/j.ymthe.2025.07.004

Elsevier

Abstract：Cytokines are promising in cancer immunotherapy, but their pleiotropic effects limit specificity and clinical utility. Through binding to IL-18Rα and IL-18Rβ, interleukin-18 (IL-18) stimulat

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