Berberine promotes β-catenin ubiquitination and inhibits its nuclear translocation by targeting USP22 in colorectal cancers

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DOI:10.1016/j.phymed.2026.157765
作者：Gang Xu,?Qihong Yang,?Shaohua Zhang,?Guangchao Ma,?Yuyang Wang,?Ying Huang,?Lingmei Kong,?Yan Li
文献类型：期刊论文
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Elsevier

Abstract：Wnt/β-catenin signaling pathway is the most frequently altered cascade in colorectal cancer (CRC), and the nucleus accumulation of β-catenin is the hallmark of the activation of Wnt/β-cateni

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