Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure

已完结 10 由小小发布于 2025/6/13 10:25:05

DOI:10.1021/acs.jmedchem.1c01504
作者：Wei Meng*,?Zulan Pi,?Robert Brigance,?Karen A. Rossi,?William A. Schumacher,?Jeffrey S. Bostwick,?Peter S. Gargalovic,?Joelle M. Onorato,?Chiuwa E. Luk,?Claudia N. Generaux,?Tao Wang,?Ruth R. Wexler,?
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：This paper describes our continued efforts in the area of small-molecule apelin receptor agonists. Recently disclosed compound 2 showed an acceptable metabolic stability but demonstrated mon

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