Development of potent dual PDK1/AurA kinase inhibitors for cancer therapy: Lead-optimization, structural insights, and ADME-Tox profile

已完结 10 由 Luke 发布于 2025/6/18 0:29:09

DOI:10.1016/j.ejmech.2021.113895
作者：Simona Sestito ,?Andrea Bacci ,?Sara Chiarugi ,?Massimiliano Runfola ,?Francesca Gado ,?Eleonora Margheritis ,?Sheraz Gul ,?Maria E. Riveiro ,?Ramiro Vazquez ,?Samuel Huguet ,?Clementina Manera ,?Keyv
文献类型：期刊论文
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Elsevier

Abstract：We report the synthesis of novel first-in-class 2-oxindole-based derivatives as dual PDK1-AurA kinase inhibitors as a novel strategy to treat Ewing sarcoma. The most potent compound 12 is su

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