Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus

已完结 10 由 Luke 发布于 2025/6/17 21:53:59

DOI:10.1158/1535-7163.mct-23-0602
作者：Chun-Ping Chang, Teng-Kuang Yeh, Chiung-Tong CHEN, Wan-Ping Wang, Yen-Ting Chen, Chia-Hua Tsai, Yan-Fu Chen, Yi-Yu Ke, Jing-Ya Wang, Ching-Ping Chen, Tsung-Chih Hsieh, Mine-Hsine Wu, Chen-Lung Huang,
文献类型：期刊论文
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American Association for Cancer Research (AACR)

Abstract：Aurora kinase inhibitors such as alisertib can destabilize MYC-family oncoproteins and have demonstrated compelling anti-tumor efficacy. In this study, we report 6K465, a novel pyrimidine-ba

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