An Engineered Prodrug Selectively Suppresses β-Lactam-Resistant Bacteria in a Mixed Microbial Setting.

已完结 10 由 phoebe9203 发布于 2025/6/18 16:29:23

DOI:10.1021/acsinfecdis.5c00179
作者：Addison M Duda, Helena R Ma, César A Villalobos, Sophia A Kuhn, Sarah S Angle, Katherine He, Abigail C Jackson, Christine M Suh, Elena A Puccio, Deverick
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：The rise of β-lactam resistance necessitates new strategies to combat bacterial infections. We purposefully engineered the β-lactam prodrug AcephPT to exploit β-lactamase activity to selecti

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