De novo design of drug-binding proteins with predictable binding energy and specificity

已完结 10 由 aokouyou 发布于 2025/6/18 15:32:40

DOI:10.1126/science.adl5364
作者：Lei Lu, Xuxu Gou, Sophia K. Tan, Samuel I. Mann, Hyunjun Yang, Xiaofang Zhong, Dimitrios Gazgalis, Jesús Valdiviezo, Hyunil Jo, Yibing Wu, Morgan E.
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：The de novo design of small molecule–binding proteins has seen exciting recent progress; however, high-affinity binding and tunable specificity typically require laborious screening and opti

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