The Discovery of C7-Substituted Norbornyl Bisamides as RXFP1 Small Molecule Agonists

已完结 10 由 Holly 发布于 2025/6/24 8:22:33

DOI:10.1021/acs.jmedchem.5c00991
作者：Shun Su, Michael C. Myers, Donna M. Bilder, Adam Clarke, Todd Friends, Thomas V. Petrone, Carol Ryan, Carol M. Krause, Ruihua Chen, Yi-xin Li, Matthew Fronheiser, Michael A. Galella, Anne V. Rose, Cla
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American Chemical Society (ACS)

Abstract：Human relaxin-2 (relaxin, H2-RLX, RLN2), an endogenous hormone associated with mammalian pregnancy, and its cognate receptor relaxin family peptide receptor 1 (RXFP1) have been implicated as

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