CRISPR screen reveals a simultaneous targeted mechanism to reduce cancer cell selenium and increase lipid oxidation to induce ferroptosis

已完结 10 由刘力发布于 2025/6/23 21:18:03

DOI:10.1073/pnas.2502876122
作者：Sophia M. Lamperis, Kaylin M. McMahon, Andrea E. Calvert, Jonathan S. Rink, Karthik Vasan, Madhura R. Pandkar, Eliana U. Crentsil, Zachary R. Chalmers, Natalie R. McDonald, Cameron J. Kosmala, Marcelo
文献类型：期刊论文
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Proceedings of the National Academy of Sciences of the United States of America (PNAS)

Abstract：Ferroptosis is a cell death mechanism distinguished by its dependence on iron-mediated lipid oxidation. Cancer cells highly resistant to conventional therapies often demonstrate lipid metabo

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