Discovery of (S)-1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain

DOI:10.1021/acs.jmedchem.1c02131
作者：Guanglin Luo*,?Ling Chen,?Walter A. Kostich,?Brian Hamman,?Jason Allen,?Amy Easton,?Clotilde Bourin,?Michael Gulianello,?Jonathan Lippy,?Susheel Nara,?Tarun Kumar Maishal,?Kamalraj Thiyagarajan,?Prasa
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