Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor

已完结 10 由 whyee 发布于 2025/5/14 11:23:57

DOI:10.1126/science.ado7082
作者：Edwin N. Neumann,?Tessa M. Bertozzi,?Elaine Wu,?Fiona Serack,?John W. Harvey,?Pamela P. Brauer,?Catherine P. Pirtle,?Alissa Coffey,?Michael Howard,?Nikita Kamath,?Kenney Lenz,?Kenia Guzman,?Michael H.
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：Prion disease is caused by misfolding of the prion protein (PrP) into pathogenic self-propagating conformations, leading to rapid-onset dementia and death. However, elimination of endogenous

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