Generation of human adult hepatocyte organoids with metabolic functions

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DOI:10.1038/s41586-025-08861-y
作者：Ryo Igarashi, Mayumi Oda, Ryo Okada, Tomoki Yano, Sirirat Takahashi, Strahil Pastuhov, Mami Matano, Norio Masuda, Kazuhiro Togasaki, Yuki Ohta, Saeko Sato, Takako Hishiki, Makoto Suematsu, Manabu Itoh
文献类型：期刊论文
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Nature

Abstract：Proliferating hepatocytes often undergo ductal metaplasia to balance the energy trade-off between cellular functions and replication, hindering the expansion of human adult hepatocytes with

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