Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

已完结 10 由杨小木发布于 2025/5/13 22:01:59

DOI:10.1021/jm300094u
作者：Antonia F. Stepan*, Chakrapani Subramanyam, Ivan V. Efremov, Jason K. Dutra, Theresa J. O’Sullivan, Kenneth J. DiRico, W. Scott McDonald, Annie Won, Peter H. D
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1021/jm300094u

American Chemical Society (ACS)

Abstract：Replacement of the central, para-substituted fluorophenyl ring in the γ-secretase inhibitor 1 (BMS-708,163) withthe bicyclo[1.1.1]pentane motif led to the discovery of compound 3, an equipot

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