Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α-Helical Peptide in Clinical Development

已完结 10 由 phyjun 发布于 2025/5/21 10:23:42

DOI:10.1021/acs.jmedchem.3c00623
作者：Vincent Guerlavais,?Tomi K. Sawyer,?Luis Carvajal,?Yong S. Chang,?Bradford Graves,?Jian-Guo Ren,?David Sutton,?Karen A. Olson,?Kathryn Packman,?Krzysztof Darlak,?Carl Elkin,?Eric Feyfant,?Kamala Kesav
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：We report the discovery of sulanemadlin (ALRN-6924), the first cell-permeating, stabilized α-helical peptide to enter clinical trials. ALRN-6924 is a “stapled peptide” that mimics the N-term

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