Reductive C(sp2)–C(sp3) Coupling Protocol to Enable Linker Exploration of Cereblon E3-Ligase BRD4 Proteolysis-Targeting Chimeras

已完结 10 由胖子发布于 2025/5/20 11:17:43

DOI:10.1021/acs.jmedchem.4c03157
作者：Kaitlyn Lovato, Danielle Loskot, Christine Gelin, Lu Zhu, Charu Chaudhry, Nadeem A. Vellore, Amanda Del Rosario, Taylor Courtney, Seth Miller, Ji-Hoon Cho, Harris Bell-Temin, Jennifer D. Venable, Jean
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Heterobifunctional degraders (also known as proteolysis-targeting chimeras or PROTACs) have emerged in drug discovery as an alternative therapeutic modality for targeting disease-causing pro

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