Route Design and Scale-Up of a Topoisomerase I Inhibitor Antibody–Drug Conjugate Payload

已完结 10 由 lindlarcat 发布于 2025/5/27 0:10:13

DOI:10.1021/acs.oprd.4c00175
作者：William R. F. Goundry*, Andrew M. Poulton, Matthew Welham, Kuangchu Dai, Xiaohong Zhu, Haijun Tao, Canlin Tang, Fanny Magne and Bertrand Cottineau, 
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：AstraZeneca is currently developing an antibody–drug conjugate for the treatment of cancer with a topoisomerase I inhibitor payload. The drug portion of the molecule is an analogue of the na

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