Domoic Acid as a Lead for the Discovery of the First Selective Ligand for Kainate Receptor Subtype 5 (GluK5).

已完结 10 由小小发布于 2025/6/3 15:33:30

DOI:10.1021/acs.jmedchem.4c01311
作者：Silke Buschbom-Helmke,?Pengfei Wang,?Anna Alcaide,?Federico Miguez-Cabello,?Mario Carta,?Julio S Viotti,?Birgitte Nielsen,?Christophe Mulle,?Derek Bowie,?Flemming Steen J?rgensen,?Darryl S Pickering,?
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：Twenty-one simplified analogues of the natural product domoic acid were designed, synthesized, and then characterized at homomeric kainic acid (KA) receptors (GluK1-3,5). LBG20304 displays a

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