Optimized Synthesis of an Abemaciclib Intermediate: Improved Conditions for a Miyaura Borylation/Suzuki Coupling Process

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DOI:10.1021/acs.oprd.4c00381
作者：Michael P. Carroll, Aobha Hickey, Ava Rogers, Cáoimhe J. Niland, Rachel A. O’Sullivan, Nachimuthu Muniraj, Kevin F. O’Sullivan, Patrick J. Guiry, Michael M. Murray
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Improved reaction conditions have been developed for a telescoped Miyaura borylation/Suzuki coupling process, which is utilized in the synthesis of an abemaciclib intermediate. Key improveme

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