A high-MAPK, low-WNT cell state drives metastatic dissemination in colorectal cancer.

已完结 10 由洛橙发布于 2026/5/13 20:19:03

DOI:10.1038/s43018-026-01155-w
作者：Melanie Heinlein,?Ginny X Li,?Noelyn Kljavin,?Amanda R Moore,?Brian Biehs,?Liming Tao,?Soufiane Boumahdi,?Farnaz Mohammadi,?Minyi Shi,?Yuxin Liang,?Hartmut Koeppen,?Nicolò Riggi,?Robert Piskol,?Frede
文献类型：期刊论文
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Nature

Abstract：Colorectal cancer (CRC), a leading cause of cancer-related mortality due to distant metastases, is largely driven by activating mutations in the WNT and mitogen-activated protein kinase (MAP

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