Identification of Thieno[3,2-d]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3

已完结 10 由 LZI 发布于 2025/1/14 13:45:42

DOI:10.1021/acs.jmedchem.1c00459
作者：Hanna Cho, Injae Shin, Hojong Yoon, Eunhye Jeon, Jiwon Lee, Younghoon Kim, SeongShick Ryu, Chiman Song, Nam Hoon Kwon, Youngji Moon, Sunghoon Kim,&nbs
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Focal adhesion kinase (FAK) is overexpressed in highly invasive and metastatic cancers. To identify novel FAK inhibitors, we designed and synthesized various thieno[3,2-d]pyrimidine derivati

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