Discovery of pyrrolopyrimidinone derivatives as potent PKMYT1 inhibitors for the treatment of cancer

已完结 10 由 Luke 发布于 2025/1/20 11:48:10

DOI:10.1016/j.ejmech.2024.117025
作者：Chao Wang ,?Yazhou Wang ,?Fanye Meng ,?Tingting Liu ,?Xiaomin Wang ,?Xin Cai ,?Man Zhang ,?Alex Aliper ,?Feng Ren ,?Alex Zhavoronkov ,?Xiao Ding
文献类型：期刊论文
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Elsevier

Abstract：The protein kinase PKMYT1 is responsible for inhibitory CDK1 phosphorylation, thus playing a central role in regulating the G2/M cell cycle checkpoint. As many cancers have dysfunctional cel

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