单链发夹环状 RNA（loopmeRNA）通过 RNA 干扰途径有效诱导基因沉默。

已完结 10 由 fuzheng 发布于 2025/1/20 13:50:28

DOI:10.1021/jacs.4c07902
作者：Krishna C Aluri,?Dhrubajyoti Datta,?Scott Waldron,?Nate Taneja,?June Qin,?Daniel P Donnelly,?Christopher S Theile,?Dale C Guenther,?Li Lei,?Joel M Harp,?Pradeep S Pallan,?Martin Egli,?Ivan Zlatev,?Mut
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Synthetic small interfering RNAs conjugated to trivalent N-acetylgalactosamine (GalNAc) are clinically validated drugs for treatment of liver diseases. Incorporation of phosphorothioate link

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