A Mechanism-Guided Strategy by Weighting Key Reaction States for Rational Engineering of ω-Transaminase toward Bulky Chiral Amines

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DOI:10.1021/acs.orglett.6c02236
作者：Lin Yang,?Xiaolan Sun,?Huilin Yang,?Weihua Zhao,?Tao Yuan*,?Xiaolan Wang* and Fen-er Chen*,?
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：A mechanism-guided strategy weighting two key reaction states, the prereaction conformation and external aldimine, enabled rational engineering of a novel ω-transaminase ATA-116 for bulky ch

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