Itaconate promotes inflammatory responses in tissue-resident alveolar macrophages and exacerbates acute lung injury

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DOI:10.1016/j.cmet.2025.05.012
作者：Mengtian Shan, Song Zhang, Zhibing Luo, Shengjie Deng, Linyu Ran, Quan Zhou, Huimin Wan, Jihui Ye, Chenchen Qian, Ximin Fan, Yun Feng, David W. Morse, Joerg Herrmann, Qiang Li, Zhongliang Guo, Feilong
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Elsevier

Abstract：Itaconate is an anti-inflammatory metabolite with therapeutic potential in multiple inflammatory diseases. However, its immunomodulatory function has been mainly based on ex vivo-generated m

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