Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036

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DOI:10.1021/jacs.2c09917
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1021/jacs.2c09917

American Chemical Society (ACS)

Abstract：An efficient asymmetric synthesis of a potent KRAS G12C covalent inhibitor, GDC-6036 (1), is reported. The synthesis features a highly atroposelective Negishi coupling to construct the key C

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