PSTK inhibition activates cGAS-STING, precipitating ferroptotic cell death in leukemic stem cells.

求助中 10 由科研篝火者发布于 2025/2/8 23:26:14

DOI:10.1182/blood.2024026040
作者：Lingli He,?Ting Zhao,?Wei Zhong Leong,?Azeem Sharda,?Christina Mayerhofer,?Shenglin Mei,?Gracia M Bonilla,?Juan Bautista Menendez-Gonzalez,?Karin Gustafsson,?Tsuyoshi Fukushima,?Trine A Kristiansen,?J
文献类型：期刊论文
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American Society of Hematology (ASH)

Abstract：Differentiation arrest and dependence on oxidative metabolism are features shared among genetically diverse acute myeloid leukemias (AML). A phenotypic CRISPR-Cas9 screen in AML identified d

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