Streamlined Synthesis of SHP2 Inhibitor GDC-1971 Enhanced by a Telescoped Schotten-Baumann SNAr and Reactive Crystallization Cascade

已完结 10 由冰凌妙妙发布于 2024/12/10 17:00:54

DOI:10.1021/acs.oprd.4c00162
作者：Lauren E. Sirois*,?Nicholas A. White,?Jeff Shen,?Derek M. Dalton,?Daniel Zell,?Frédéric St-Jean and Francis Gosselin,?
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：An improved synthetic process for SHP2 inhibitor GDC-1971 (migoprotafib) was developed to address challenges associated with the scalability and robustness of a preliminary fit-for-purpose r

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