Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists

已完结 10 由 dicer 发布于 2024/12/10 11:17:26

DOI:10.1126/science.adp1779
作者：Matthias Gl?gl, Aditya Krishnakumar, Robert J. Ragotte, Inna Goreshnik, Brian Coventry, Asim K. Bera, Alex Kang, Emily Joyce, Green Ahn, Buwei Huang, Wei Yang, Wei Chen, Mariana Garcia Sanchez, Brian
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：Despite progress in designing protein-binding proteins, the shape matching of designs to targets is lower than in many native protein complexes, and design efforts have failed for the tumor

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