Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis

已完结 10 由小小发布于 2024/12/12 14:43:23

DOI:10.1021/acs.jmedchem.3c01986
作者：Xiaojun Zhang*,?Wen Jiang,?Jeremy M. Richter*,?J. Alex Bates,?Samuel K. Reznik,?Sylwia Stachura,?Richard Rampulla,?Dyamanna Doddalingappa,?Sankar Ulaganathan,?Ji Hua,?Jeffrey S. Bostwick,?Chi Sum,?Sha
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：PAR4 is a promising antithrombotic target with potential for separation of efficacy from bleeding risk relative to current antiplatelet therapies. In an effort to discover a novel PAR4 antag

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