Discovery of Potential First-in-Class Dual Ligand-Directed Degrader and Antagonist of the Androgen Receptor: BMS-986365.

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DOI:10.1021/acs.jmedchem.6c01590
作者：Deborah S Mortensen,Surendra Nayak,Veronique Plantevin-Krenitsky,Evan J Horn,Joseph Meiring,Samantha Reiss,Kimberly Peacock,Jingjing Zhao,Xiaochu Ba,Stephen Norris,Matt Alexander,Matthew Correa,Dehua
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Androgen receptor (AR) signaling is central to the progression of prostate cancer, including castration-resistant disease. Targeted protein degradation, particularly through heterobifunction

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