Development of a Scalable Synthesis of a Drug-Linker for ABBV-3373

已完结 10 由陌上花开发布于 2024/12/20 10:46:42

DOI:10.1021/acs.oprd.3c00447
作者：Nathan B. Bennett*,?Bradley D. Gates,?Justin A. Simanis,?James W. Treadway,?Steven M. Richter and Dennie S. Welch,?
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：A scalable process to produce glucocorticoid-bearing drug-linker 1, utilized in the conjugation with the monoclonal antibody (mAb) adalimumab, has been developed. The route improves upon the

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