Development of a Scalable Asymmetric Process for the Synthesis of Selective PDE4B Inhibitor Nerandomilast (BI 1015550)

已完结 10 由小书童发布于 2025/3/5 20:53:03

DOI:10.1021/acs.oprd.4c00309
作者：Rogelio P. Frutos, Thomas G. Tampone, Frank Gerstmann, Dirk Weber, Tobias Brodmann, Robert Hagenk?tter, Jocelyn Abella, Bing-Shiou Yang, Jason Mulder, Sonia Rodriguez, Heewon Lee, Joe Gao, Jinhua J. S
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：A robust and scalable synthesis process for Nerandomilast (1, BI 1015550), a selective PDE4B inhibitor with potential therapeutic properties for the treatment of respiratory diseases, was de

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