RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation.

已完结 10 由 Tricia①① 发布于 2025/3/7 0:01:11

DOI:10.1016/j.ccr.2013.03.033
作者：Matthew Holderfield 1, Hanne Merritt , John Chan , Marco Wallroth , Laura Tandeske , Huili Zhai , John Tellew ,
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1016/j.ccr.2013.03.033

Elsevier

Abstract：ATP competitive inhibitors of the BRAF(V600E) oncogene paradoxically activate downstream signaling in cells bearing wild-type BRAF (BRAF(WT)). In this study, we investigate the biochemical m

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