Neuronal FAM171A2 mediates α-synuclein fibril uptake and drives Parkinson's disease.

已完结 10 由 Holly 发布于 2025/3/13 16:15:21

DOI:10.1126/science.adp3645
作者：Kai-Min Wu,?Qian-Hui Xu,?Yi-Qi Liu,?Yi-Wei Feng,?Si-Da Han,?Ya-Ru Zhang,?Shi-Dong Chen,?Yu Guo,?Bang-Sheng Wu,?Ling-Zhi Ma,?Yi Zhang,?Yi-Lin Chen,?Liu Yang,?Zhao-Fei Yang,?Yu-Jie Xiao,?Ting-Ting Wang,
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：Neuronal accumulation and spread of pathological α-synuclein (α-syn) fibrils are key events in Parkinson's disease (PD) pathophysiology. However, the neuronal mechanisms underlying the uptak

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