A pH?responsive hydrogel delivering ISOC1 modRNA attenuates disc degeneration by promoting BIRC6?mediated MYC degradation and inhibiting SBSN expression.

已完结 10 由 benpaoxiaoxiong 发布于 2026/7/15 11:11:02

DOI:10.1186/s12951-026-04748-w
作者：Kun Wang,?Zhiqiang Wang,?Yanzheng Gao,?Rui Sun,?Guowang Zhang,?Xiaofeng Lian,?Xin Peng
文献类型：期刊论文
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Springer

Abstract：Intervertebral disc degeneration (IDD), a principal cause of chronic low back pain, is characterized by nucleus pulposus cell (NPC) apoptosis and currently lacks effective therapies. Through

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