Metabolically Stable Adenylation Inhibitors of Biotin Protein Ligase as Antibacterial Agents

已完结 10 由科技工信局发布于 2025/3/17 15:34:19

DOI:10.1021/acs.jmedchem.4c02299
作者：Qiang Liu, Curtis A. Engelhart, Joshua B. Wallach, Divya Tiwari, Peng Ge, Adhar Manna, Subhankar Panda, William M. McCue, Tsung-Yun Wong, Sachin Sharma, Yahani P. Jayasinghe, Jessica Fuller, Donald R.
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：The antibacterial agent Bio-AMS is metabolized in vivo through hydrolysis of the central acyl-sulfamide linker leading to high clearance and release of a moderately cytotoxic metabolite M1.

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