Rapid in silico directed evolution by a protein language model with EVOLVEpro

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DOI:10.1126/science.adr6006
作者：Kaiyi Jiang, Zhaoqing Yan, Matteo Di Bernardo, Samantha R. Sgrizzi, Lukas Villiger, Alisan Kayabolen, B. J. Kim, Josephine K. Carscadden, Masahiro Hiraizumi,&nb
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American Association for the Advancement of Science (AAAS)

Abstract：Directed protein evolution is central to biomedical applications but faces challenges such as experimental complexity, inefficient multiproperty optimization, and local maxima traps. Althoug

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