The impact of E3 ligase choice on PROTAC effectiveness in protein kinase degradation

已完结 10 由 jxxjxx 发布于 2025/3/23 11:53:18

DOI:10.1016/j.bioorg.2024.107204
作者：Hidetomo Yokoo, Genichiro Tsuji, Takao Inoue, Mikihiko Naito, Yosuke Demizu, Nobumichi Ohoka
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1016/j.bioorg.2024.107204

Elsevier

Abstract：Proteolysis targeting chimeras (PROTACs) induce the ubiquitination and subsequent proteasomal degradation of targeted proteins. Numerous PROTACs have emerged as promising drug candidates for

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