Transferrin receptor targeting chimeras for membrane protein degradation

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DOI:10.1038/s41586-024-07947-3
作者：Dingpeng Zhang, Jhoely Duque-Jimenez, Francesco Facchinetti, Garyk Brixi, Kaitlin Rhee, William W. Feng, Pasi A. J?nne, Xin Zhou
文献类型：期刊论文
补充材料：仅需补充材料

Nature

Abstract：Cancer cells require high levels of iron for rapid proliferation, leading to significant upregulation of cell-surface transferrin receptor 1 (TfR1), which mediates iron uptake by binding to

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