Hemodynamic effects of carvedilol plus simvastatin in cirrhosis with severe portal hypertension and suboptimal response to β-blockers: A double-blind, placebo-controlled, randomized-trial

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DOI:10.1097/hep.0000000000001148
作者：Edilmar Alvarado-Tapias, Anna Brujats, Angela Puente, Alba Ardevol, Ainhoa Rodriguez-Arias, Javier Fajardo, Oanna Pavel, Marta Garcia-Guix, Carles Aracil, Maria Poca, Berta Cuyàs, Elisabet Cantó, Ro
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Wolters Kluwer Ovid

Abstract：Background Aims: Carvedilol is a non-selective β-blocker (NSBBs) with anti-α1-adrenergic activity, more effective than traditional NSBBs in reducing portal-pressure (HVPG). However, 35%-45%

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