Selective Metalation of Functionalized Quinazolines to Enable Discovery and Advancement of Covalent KRAS Inhibitors

已完结 10 由小太阳发布于 2025/2/22 11:18:44

DOI:10.1021/acs.oprd.2c00242
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1021/acs.oprd.2c00242

American Chemical Society (ACS)

Abstract：The quinazoline compound ARS-1620 is a recently discovered, mutant-specific covalent inhibitor of KRASG12C. Route scouting in support of multigram ARS-1620 batches led to a new synthetic app

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