Engineering the Cyclization Loop of MCoTI-II Generates Targeted Cyclotides that Potently Inhibit Factor XIIa

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DOI:10.1021/acs.jmedchem.2c01080
作者：Sixin Tian, Thomas Durek, Conan K. Wang, Christina N. Zdenek, Bryan G. Fry, David J. Craik* and Simon J. de Veer*, 
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Factor XIIa (FXIIa) is a promising target for developing new drugs that prevent thrombosis without causing bleeding complications. A native cyclotide (MCoTI-II) is gaining interest for engin

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